Authored by Ross Pomeroy via RealClearScience,
For years, scientists have hypothesized that safe, cheap, generic drugs like metformin and rapamycin could slow aging, based on promising findings in animal models. But despite the evidenced hope, little has been done to see if these drugs actually slow aging in humans. There have been no rigorous clinical trials exploring whether metformin or rapamycin prolong life and and boost health.
How is it possible that metformin and rapamycin, long used to respectively treat diabetes and prevent organ transplant rejection, have had their anti-aging potential ignored for so long? To conspiracy-minded critics of 'Big Pharma', the answer is obvious: there's no money in it. In this case, they seem to be correct. Speaking at the 12th Aging Research and Drug Discovery (ARDD) meeting convened at the University of Copenhagen last summer, industry leaders conceded the point.
"Repurposing cheap, off-patent drugs like metformin fails mathematically. Phase 3 clinical trials cost hundreds of millions of dollars. Companies cannot recover this money without a patent monopoly. Therefore, the industry tests new, patented drugs for specific diseases."
Rapamycin costs between $40 and $150 per month out of pocket. Metformin is even cheaper, between $4 and $20 pe
