Authored by George Citroner via The Epoch Times,

A specific variation in the vitamin D receptor gene may determine whether high-dose supplementation lowers diabetes risk in prediabetic people.

Nearly 115 million Americans are on the road to diabetes.New research suggests an inexpensive, widely available supplement could slow that journey, but only for some of them.

A genetic quirk in roughly 70 percent of prediabetic adults may determine whether high-dose vitamin D can meaningfully lower their risk of developing Type 2 diabetes, according to a study published in JAMA Network Open.

The research builds on the D2d trial.More than 2,000 U.S. adults living with prediabetes were randomized to either take 4,000 units of vitamin D or a placebo for up to 3.5 years. Initially, the trial did not find any significant changes across the participants. The recommended daily allowance is 600 to 800 units for average adults.

However, when scientists analyzed participants' DNA, a more nuanced picture emerged: those carrying specific variations - known as AC or CC - in a gene called ApaI responded strongly to supplementation. Over the 3.5 years of the study, participants carrying the AC or CC variant had a 19 percent lower chance of developing diabetes. The roughly 30 percent with the AA variation saw no benefit at all.

"Diabetes has so many serious complications that develop slowly over years," study lead researcher Bess Dawson-Hughes said in a statement. "If we can delay the time a person spends living with diabetes, we can reduce some of those harmful side effects or lessen their severity."

The distinction matters because prediabetes - defined by higher-than-normal blood sugar that hasn't yet crossed into diabetes territory - affects more than two in five U.S. adults, and often progresses silently. Identifying who stands to benefit from vitamin D intervention could allow clinicians to target supplementation far more precisely than current blanket guidelines allow.

Vitamin D in the blood is converted into its active form in the body. Vitamin D receptors are highly prevalent and present in many cells throughout the body.

When vitamin D binds to cell receptors, it helps cells do what they are supposed to do. In pancreatic cells, vitamin D facilitates the release of insulin to regulate blood sugar.

Source: ZeroHedge News