As the search for Nancy Guthrie enters the third week, an unidentified male DNA profile recovered from aglove foundabout two miles from her home has been entered into the FBI's national DNA database but did not produce any matches, the sheriff of Pima County said on Tuesday. Sheriff Chris Nanos toldFox News,that the profile had been submitted to the Combined DNA Index System, known as CODIS, and returned no hits.

"We're hopeful that we're always getting closer, but the news now, I think, is we had heard this morning that, of course, the DNA on the glove that was found two miles away was submitted for CODIS," Sheriff Nanos said. "And I just heard that, CODIS had no hits." The FBI confirmed to Fox News that the profile had been processed through the database without a match.

Sheriff Nanos also said that DNA recovered from inside Guthrie's home had likewise failed to match any records in the federal system. He added that the genetic material found on the glove was different from the DNA collected inside the residence.

Nancy Guthrie with her daughter Savannah Guthrie. (Photo: AP)

More than two weeks after Nancy Guthrie was reported missing, investigators say they are still working to identify a suspect, as the case continues to distress her family — most visibly her daughter, the "Today" show host Savannah Guthrie, who has issued public appeals for information.

On Monday, Sheriff Chris Nanos said Guthrie's three children and their spouseshad been ruled outas suspects and described them as victims. He urged an end to speculation about the family. "The family has been nothing but cooperative and gracious," he said.

The sheriff's office says it has received tens of thousands of tips, conducted ground and aerial searches of the neighbourhood and enlisted assistance from the FBI and other agencies. However, authorities have not identified a suspect and say they do not know whether Guthrie is still alive. Investigators are operating under the assumption that she could be in imminent danger, Lance Leising, a retired FBI agent based in Phoenix, toldThe New York Times.

The home of Nancy Guthrie, the missing mother of 'Today' show host Savannah Guthrie, where the FBI conducted a search. (Photo: AP)

"When you do that, you run the risk of hitting dry holes, of swinging and missing," Leising said, adding that the public is likely aware of only "5 percent of what investigators know".

On Friday night, officers carried out an operation that followed a similar development days before in Rio Rico, Arizona, about an hour south of Tucson. One man was detained and questioned for several hours. Sheriff Nanos said at the time he believed his team had solved the case, but investigators later acknowledged they had reached a dead end. The man was released. Police say Guthrie was taken in the early hours of February 1.

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