A bitter internal clash over mango-flavoured vapes, mounting White House frustration and intensifying political pressure appear to have ended Marty Makary's short and turbulent tenure atop America's top drug regulator.

The resignation of FDA Commissioner Marty Makary has triggered speculation over whether US President Donald Trump effectively forced him out after weeks of public criticism and behind-the-scenes disputes over flavoured vaping products. While the White House insists Makary resigned voluntarily, several reports suggest the relationship between the pair had deteriorated sharply in recent days.

At the centre of the fallout was an increasingly contentious debate surrounding fruit-flavoured electronic cigarettes, particularly mango vape products that had become a lightning rod inside Trump's administration. Makary reportedly resisted approving certain flavoured vape products because of concerns about youth appeal and public health risks. However, Trump allies and vaping industry advocates pushed aggressively for approval, arguing that regulated products would help weaken the black market and protect small businesses.

The controversy intensified after the FDA approved severalfruit-flavoured vape productsearlier this month, including mango and blueberry varieties produced by Glas Inc. The products included age-verification technology designed to prevent underage purchases, but critics argued the flavours would still appeal to teenagers.

Reports indicate Makary had initially delayed the approvals, frustrating Trump and several senior administration officials. According toreports, Trump openly criticised the delays and questioned why the FDA commissioner was moving slowly on the issue. The dispute reportedly became one of the defining tensions of Makary's final weeks in office.

The FDA eventually approved the products after pressure from the White House, but the reversal did little to ease tensions. Sources close to the administration said the decision exposed deeper divisions over how aggressively the agency should support vaping as a smoking alternative.

"Trump recently became frustrated with Makary for not moving fast enough to approve flavored vapes and other nicotine products. Makary refused to authorize blueberry and mango vape flavors from LA manufacturer Glas, worried that fruit flavors would encourage youth vaping. After…

Officially, the answer remains no. In aninterview, Trump publicly described Makary as 'a great doctor' and 'a friend', while confirming that the commissioner was stepping down.

Yet multiple reports suggest Makary's resignation came after Trump had already discussed removing him.Reports indicatedthat Trump had signed off on plans to remove the FDA chief days before the resignation became public.

That has fuelled widespread speculation that Makary effectively resigned before he could be formally dismissed.

Source: International Business Times UK